Cannabis-Induced Brugada Syndrome Presenting as Cardiac Arrest

Brugada syndrome (BrS) is an inherited sodium channelopathy, which can precipitate malignant ventricular arrhythmias and sudden cardiac death [1]. Characteristic electrocardiographic features without underlying structural heart disease make the diagnosis, and certain drugs can unmask the abnormality on electrocardiography (ECG). While sinus tachycardia is a known side effect of cannabis use, Brugada pattern on ECG and ventricular arrhythmias in the setting of BrS are much less known consequences and should be considered in young patients presenting with cardiac arrest without other risk factors. Despite increasing use of marijuana and evidence of its cardiovascular effects, there is a paucity of case reports and the pathogenesis of marijuana-induced BrS remains unknown. This case highlights the diagnostic and clinical challenge of BrS and a raises the issue of cannabis as a potential provoking agent of malignant arrhythmias in BrS.